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The recycling process involves protein kinases as shown by staurosporine, which increases recycling and resensitization after [Met 5 ]-enkephalin exposure (Arttamangkul et al., 5 ]-enkephalin- or morphine-induced acute desensitization but not cellular tolerance involves dephosphorylation mediated by protein phosphatases sensitive to calyculin A but not okadaic acid (Levitt and Williams, 2012)

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