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The HRH2 gene is also expressed in additional cells of the gastrointestinal tract, cells of the central nervous system, smooth muscle cells, endothelial cells, and cardiomyocytes
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Other malignancies, including urinary tract, stomach, and small intestine cancers, have also been linked to MSH6 mutations, though they occur less frequently ( 2.1.3 PMS1 homolog 2 ( PMS2 ) A defective PMS2 gene associated with LS substantially elevates the possibilities of developing specific cancers, particularly CRC and EC in comparison to the general population
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