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Indeed some practices achieve dramatic change: One practice reduced the number of patients on B12 injections from 53 to just two

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As systemic metabolic function improves, secondary benefits such as enhanced muscle definition, improved skin tone, and overall physical refinement may be observed, reflecting improved cellular energy balance and reduced inflammatory burden

(Wu et al., 2019) demonstrated in human umbilical vein ECs and arteries of HHcy mice that Hcy triggers the expression of ER oxidoreductin-1 (Ero1), leading to ER stress and subsequent inflammation

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