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In CLL, leukemia progression consists of recirculation of cancer cells from the blood to the lymphoid organs, and this process is coordinated by the chemokine CXCL12 and its receptor CXCR4 [31]
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Early human safety work suggested AOD-9604 was generally well tolerated, with a placebo-like adverse-event profile and no IGF-1 elevation [5] [6]
