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Colistin was introduced in the clinic in 1961 with the expectation, by the scientific community, of finally filling the void in the treatment of challenging infections such as those from antibiotic resistant Pseudomonas aeruginosa [4]

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Some of the B12 from the liver is excreted in the bile and reabsorbed in the intestines through a process known as enterohepatic circulation (Shibboleth Authentication Request, n.d.)

Penetration through the skin barrier is limited, particularly for larger molecules, and results depend heavily on the delivery vehicle and formulation