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Glutathione and hallmarks of aging: A study in older adults (n=48, aged 60-80) found that GlyNAC supplementation for 16 weeks improved several molecular hallmarks of aging, including mitophagy, nutrient sensing (reduced mTOR activation, increased AMPK signaling), inflammation (reduced NF-kB activation), and genomic instability (reduced 8-OHdG), alongside increased telomerase activity (Kumar et al., Aging, 2023) [31]

Urinary tract infections (UTIs) are not specifically associated with GLP-1 medications in clinical trials, unlike SGLT2 inhibitors which do increase UTI risk

The survey was also self-administered, so it is possible that although participants were told to do it within one hour of wakening, the investigators were not present when the survey was completed to ensure this

However, in a Phase III trial (143 patients), the pre-administration of oral pregabalin during OHP infusion did not improve the chronic pain, life quality, or mood of the cancer patients [180]