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Jenuwein T, Allis CD

What they found: Oral AOD-9604 reduced body fat by 18 to 22 % vs placebo, comparable to injection administration No changes in total body weight (because lean mass rose slightly) Decrease in plasma triglycerides by 30 % Decrease in resting free fatty acids (paradoxically, mobilization of fat from depots into oxidation) No GI side effects Why it matters: It suggested that AOD-9604 could work orally , a rare property for a peptide

Biomedicines 2022

Mechanistic plausibility is largely theoretical pending human confirmation

Full-body cryotherapy This chilly biohack involves standing in a specialized chamber for 23 minutes in dry air ranging from -110F to -180F, with some chambers plunging as low as -230F