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Functional interactions of the cystine/glutamate antiporter, CD44v and MUC1-C oncoprotein in triple-negative breast cancer cells

doi: 10.3945/jn.114.202093

ROS production is an immune response against inhaled pathogens and pollutants like cigarette smoke, automobile exhaust

The cortex tissue in all animals was divided into 2 halves: the left half was used to determine monoamine levels, while the right half was used to measure oxidative stress

Since many pathologic and toxic conditions result in sustained increase in cytosolic free Ca 2+ , which can lead to activation of CMK and phosphorylation of GCLC, theoretically, inhibition of GCL may further contribute to toxicity under these conditions