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The authors systematically evaluated conflicting findings regarding DSIP's sleep-promoting effects, noting that while initial studies showed dramatic increases in slow-wave sleep, subsequent research produced more variable results depending on species, administration route, and baseline sleep states

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[3] Subsequent structural optimization introduced the N-terminal tyrosine residue, yielding the compound now designated AOD-9604

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[DOI] [PubMed] [Google Scholar] 6.Jensen MD, Ryan DH, Apovian CM, Ard JD, Comuzzie AG, Donato KA, Hu FB, Hubbard VS, Jakicic JM, Kushner RF, Loria CM, Millen BE, Nonas CA, Pi-Sunyer FX, Stevens J, Stevens VJ, Wadden TA, Wolfe BM, Yanovski SZ G