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In addition, GSK 3 is phosphorylated and inactivated by the activation of PI3K/Akt pathway, and therefore, inactivated GSK 3 prevents the phosphorylation of cyclin D1, inhibits the expression of cyclin D1 gene (CCND1), and accumulates cyclin D1 at the nucleus of breast cancer cells (42)

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53.85%) and a trend toward higher implantation rates (42.68% vs

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