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10.1016/J.INTIMP.2023.109813 [DOI] [PubMed] [Google Scholar] Ramanathan L, Gulyani S, Nienhuis R, Siegel JM (2002) Sleep deprivation decreases superoxide dismutase activity in rat hippocampus and brainstem

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Curcumin is often described as a hormetic compound because it induces an adaptive stress response: it mildly stresses cells in ways that activate Nrf2 and other transcription factors, leading to increased production of antioxidant and cytoprotective proteins (e.g., heme oxygenase-1) that precondition cells against subsequent injuries (77, 78)

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Use of Cu chelators and Cu ionophores have yielded encouraging anticancer activities in many preclinical models