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Ischaemia reperfusion injury in liver transplantation: Cellular and molecular mechanisms

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Mangan JJ 3rd, Tadley M, Divi SN, Stull JD, Goyal DKC, McKenzie JC, Casper DS, Galetta MS, Kaye ID, Kurd MF, Woods BI, Radcliff KE, Rihn JA, Anderson DG, Hilibrand AS, Kepler CK, Vaccaro A.R., Schroeder GD

Petri S, Krner S, Kiaei M

Gut microbiota, by converting curcumin into more active metabolites through its enzymatic activity, becomes the protagonist of the pharmacokinetics and pharmacodynamics of this polyphenol (Pan et al., 2019) and, therefore, takes on a fundamental role not only in the metabolism but also in its efficacy, toxicity, and bioavailability, once administrated orally to the host (Dey, 2019)