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Alanine, arginine, cysteine, and proline, but not glutamine, are substrates for, and acute mediators of, the liver--cell axis in female mice

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Consequently, these mice display increased energy expenditure and are protected against HFD-induced fat mass accumulation and glucose intolerance

Among them, 1672 CT substitution in SLC22A4 exon 9 that leads to the L503F mutation, prevalently in Caucasian population, heightens development risk of IBDs and sporadic colorectal cancer in early age ( 10 times more Na + ion extracellularly than intracellularly) across the plasma membrane endows a robust driving force for EGT influx into cells and its avid retention there without comparable efflux [15, 36, 37]