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[5] [4] The long-term use of nicotinic acid at greater than or equal to 2 grams per day also significantly increases the risk of cerebral hemorrhage, ischemic stroke, gastrointestinal ulceration and bleeding, diabetes, dyspepsia, and diarrhea

75A , 12651275 (1993)

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Furthermore, underlying conditions such as anemia, thyroid issues, or sleep disturbances may exacerbate tiredness

Blackwell Publishing, Oxford, U.K: (2006)