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GO and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis indicated that GDF11 supplementation enhanced angiogenesis and cell migration, promoted protein phosphorylation, and activated the PI3K-AKT signaling pathway (Fig

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Funding Statement This work was supported by the National Priorities Research Program grant NPRP 14S0311210033, awarded to Dietrich Bsselberg (January 2023Current) from the Qatar National Research Fund (QNRF, a member of the Qatar Foundation)

These combined experiments, uncover some distinctive features between the GDF11 and GDF8 mature domains in vivo , suggesting that the endogenous mature ligands are functionally different

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