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When food stays in the stomach too long, it raises the risk of reflux
The first is related with the direct impact on any main or secondary PK or PD pathways of the co-administered drug, and the second (indirect) is through the modulation of the gut microflora by antibiotic therapy that can impact the absorption processes of several medications that are administered per os [22,23,24]
Intracellular generation of acetate is the consequence of the ubiquitously expressed cytosolic enzyme acetyl-CoA hydrolase
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