kb glutathione users Mitochondrial metabolism regulates macrophage biology PRDX6 dictates ferroptosis sensitivity by
Description
The study showed that rutin can target the Cys 151 of Keap1, and form an adduct with Keap1 which results in Nrf2 activation and upregulation of glutamate cysteine ligase, a glutathione biosynthesis rate-limiting enzyme which plays an important role in the endogenous antioxidant system (Sthijns et al., 2017)
Targeting selective autophagy and beyond: from underlying mechanisms to potential therapies
Jan 2011;31(1):48-54
doi: 10.1152/jappl.1999.87.4.1381 160 LeeC
Mutations in COQ4, an essential component of coenzyme Q biosynthesis, cause lethal neonatal mitochondrial encephalomyopathy
