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Fluorescence analysis showed that Nrf2, HO-1 and SOD levels were slightly increased in cells damaged by noise, revealing an adaptive stress response

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This interconnectivity means that chronic pain in comorbid conditions is often multimechanistic, involving concurrent elements of nociceptive (e.g., joint damage in obesity), neuropathic (e.g., nerve compression in cancer, metabolic injury in diabetes), and nociplastic (e.g., central sensitization fueled by systemic inflammation) pain

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In addition, S-Acetyl glutathione has been found to increase intracellular glutathione and improve many biomarkers of oxidative stress

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Moreover, immunoblot analysis using GSNOR-specific antibody demonstrated only a slight change of GSNOR protein amount during paraquat treatment ( Figure 1B )

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