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Additionally, inflammation-induced oxidative stress can degrade drugs 70,74,75
Huang Y, Yu Q, Liu H, Xue C, Schnakers C, Laureys S, Monti MM, Di H

Conformational changes in the CsiD protein were not observed in any of the complexed structures, independently of whether ligand site I or site II was occupied

Johns wort, as mentioned, is a potent inducer of drug metabolism and should be avoided entirely during cancer treatment
doi: 10.1186/S12964-025-02434-2 157