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The feedback mechanism involves calcium-sensing receptors (CaSR) in the parathyroid chief cells that sense elevated ionized calcium level, thus inhibiting PTH release and 1,25(OH) 2 D 3 synthesis [17]

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Hence, we present the molecular interactions and binding poses of selected flavonoids (anthocyanidin such as the cyanidin-3- O -glucoside and (/+)-catechins such as ()-epicatechin and (+)-catechin) in the catalytic pocket of mh-Tyr (in absence of mammalian tyrosinase crystal structure) using computational approaches

This process is primarily driven by myofibroblasts, which originate from resident fibroblasts exposed to fibrogenic factors, such as transforming growth factor beta (TGF-1), or other ECM components