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Of the cases with induced nephrotoxicity presented in the literature, by far the most common renal lesion is TMA, which is characterized by profound endothelial swelling known as endotheliosis and may be associated with both nephrotic and subnephrotic levels of proteinuria (for review see [18, 30, 53, 6872])

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For individuals in Stage 3 burnout, a full recovery can take 12-24 months or longer and almost always requires dedicated professional guidance