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The main reasons for vitamin B12 deficiency are: Dietary deficiency, mainly in vegans and vegetarians Pernicious anemia , an autoimmune condition affecting intrinsic factor production Malabsorption due to gastrointestinal disorders or surgery Folate Deficiency-Related Megaloblastic Anemia Folate is also vital for DNA and red blood cell production

This pathological iron overload provides a continuous substrate for the Fenton reaction, constituting a fundamental and persistent risk factor driving lipid peroxidation and inducing ferroptosis (Zhang Y

Historically, the male reproductive tract was viewed as a sterile compartment, but modern high-throughput sequencing technologies have revealed that semen and prostatic fluid harbor unique low-biomass microbial communities

Therefore, promoting synaptic regeneration, improving synaptic function, and repairing damaged nerve cells have become innovative strategies for treating depression [54]