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Pre- and post-treatment of kindled rats with either GbE or LC significantly alleviated the changes in monoamine (NE, DA, and 5-HT) levels in the rats hippocampus and hypothalamus

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These studies showed that through the targeted elimination of mutated mtDNA, a beneficial shift in heteroplasmy and improvement in the biochemical deficit can be achieved [62,63,64,65,66,67]

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These crucial intermediates (fatty acyl-CoA thioesters) undergo metabolism through mitochondrial -oxidation pathways, which involve a series of enzymes located either in the inner mitochondrial membrane or mitochondrial matrix (Fig

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