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Simultaneously, copper overload can impair the cellular antioxidant defense system, exacerbating oxidative injury (123-125)
The brain tissue of PD patients is typically characterized by the death of dopaminergic, neuromelanin-containing neurons in the area of locus coeruleus and substantia nigra
mutans , and S
Giguelay, A
In addition to redox homeostasis, SOD1 plays a critical role on intracellular copper buffering 128
