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During flares, inflammatory cytokine levels spike, complement is consumed, and tissue damage accelerates

The TGA codon, encoding Sec, is found in the first exon of the human GPx-1 gene at amino acid 48 (of about 203 total), and it is located 105 nucleotides from the splice junction, suggesting that the GPx-1 gene transcript may be susceptible to nonsense-mediated decay

Chapman IM, Hartman ML, Straume M, Johnson ML, Veldhuis JD, Thorner MO

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Here we review the importance of oxidative stress and the mechanisms through which oxidative stress contributes to the pathological states of an organism