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These metabolic disorders include changes in glucose and FA transport from the extracellular environment into the cytoplasm, anaerobic glycolysis in the cytoplasm, and mitochondrial oxidative phosphorylation (Peterzan et al., 2017)

& Essaadouni, L

The activation of mTORC1 by leucine occurs through sensing mechanisms including Sestrin2 and leucyl-tRNA synthetase, which facilitate the phosphorylation of downstream effectors such as p70 S6 kinase 1 and 4E-BP1, thereby initiating translation and augmenting myofibrillar protein synthesis

Neuroprotective action of valproic acid accompanied of the modification on the expression of Bcl-2 and activated caspase-3 in the brain of rats submitted to ischemia/reperfusion