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Cmax, AUC and T values after SB + SPA treatment were comparable with values reported by Brusilow 7 and MacArthur 37

By activating both incretin pathways, tirzepatide enhances insulin secretion in a glucose-dependent manner, suppresses glucagon release, delays gastric emptying, and reduces appetite through central nervous system effects

Besides, AR transcription is further downregulated through methylated CpG islands at the AR promoter [74]

