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However, critical gaps persist: many underdeveloped regions lack robust surveillance, nonmotor symptoms remained underreported, and sexdisaggregated data show inconsistencies [40, 41, 52, 56]

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However, forced overexpression of PRDX5 significantly protects tendon cells, reducing H 2 O 2 -induced apoptosis by nearly half and preventing the decline in collagen synthesis (Yuan et al., 2004)

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Metal-based systems (MnO, Cu 2 , Fe 3 ) deplete GSH and generate ROS, with imaging potential, though metal toxicity and accumulation are concerns