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While androgen levels also decrease with age, they often decline more slowly than estrogen

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However, data from these conditional knockouts must be interpreted with caution as the authors of the study have pointed out that the Col12 promoter-driven Cre recombinase was also highly active in muscle and other non-skeletal tissues ( igf-1r generated via an osteocalcin promoter-driven Cre recombinase have excellent postnatal survival with growth rates that resemble wild-type animals