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However, this is an intermediate process, not the final result, and the mechanism behind the final cell death is still unclear

I.CoelhoR.BarbosaM

Senescent cells adopt an irreversible senescence-associated secretory phenotype (SASP), releasing soluble factors such as interleukins, chemokines, and growth factors 25 , 26

Changes in the levels of cytokines, such as tumor necrosis factor alpha (TNF-) and interleukin-6 (IL-6), are correlated with the prognosis in patients with sudden hearing loss [44]

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