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70 , 176 In contrast, polymeric carriers composed of synthetic or natural polymers such as PLGA or PEG enable controlled delivery of ferroptosis inducers (eg, erastin, RSL3, siRNA targeting GPX4 or plasmids encoding shGPX4) into the tumour microenvironment

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IRAK-4- and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans

Additionally, molecular analysis indicated that up-regulation of -arrestin2, an intracellular protein involved in the desensitization and internalization of dopamine receptors and activation of alternative signaling pathways, may be associated with reduced severity of dyskinesia in levodopa-benserazide-loaded PLGA nanocarrier-treated PD rats