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The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity

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doi: 10.7861/clinmedicine.15-2-145

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The 2017 foundational studies confirmed that 5amino1mq reduces NAD consumption via NNMT inhibition, improves glucose clearance, and decreases fat accumulation.In subsequent years, the scope expanded: a 2021 study in obese mice validated its antiobesity effects, and 2024 research revealed improvements in muscle function in aged mice.To date, the compound remains in the preclinical research stage, with no largescale human clinical trials or FDA approval for human use