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The observed reduction in serum LPS levels, coupled with downregulated hepatic TLR4 expression, provides a mechanistic link between the gut microbiota remodeling and the attenuated hepatic inflammatory response, indicating that preventive administration of Yam ELNs may at least partially alleviate liver injury through modulation of gut-derived inflammatory signals

doi: 10.3389/fcell.2026.1760517 Received 04 December 2025 Revised 02 March 2026 Accepted 16 March 2026 Published 31 March 2026 Volume 14 - 2026 Edited by Bridget Martinez, University of Nevada, Reno, United States Reviewed by Raja Singh Paulraj, Marshall University, United States Dongling Dai, Shenzhen Childrens Hospital, China Updates Copyright 2026 Zhang, Tang, Chen, Akanyibah and Mao