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Although the specific relationship between the cholinergic system and AD ferroptosis is not clear, as research deepens, cholinesterase inhibitors, M1/M4 muscarinic receptor agonists, and presynaptic choline transporters are being developed, which may help alleviate the progression of AD ferroptosis and improve clinical symptoms such as cognitive disorders, memory impairments, and spatial disorientation

SnRK2 kinases emerge as crucial nodes linking stress perception to diverse downstream responses, including gene activation, ROS production, and ion flux regulation

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Nat Commun (2016) 7:11624