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Notably, while neuronal elements (axons, neurons, dendrites, and synapses) are also damaged to a significant extent (Mck et al., 2021), demyelination is a constant finding in both white and gray matter regions pointing to the myelinating unit (the myelin sheath and oligodendrocyte) as a key target in this disease

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Furthermore, ER regulates the glutamine metabolism by crosstalking with HER2 signaling in a way dependent on c-MYC in aromatase inhibitor-resistant breast cancer cells (186)

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