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They comprise diverse subpopulations characterized by their ontogeny and polarization state ( During the resolution of inflammation, macrophages accumulate glutamine from the extracellular environment or through the engulfment of apoptotic cells and break it down into the TCA cycle intermediate -ketoglutarate ( Recent studies suggest that crosstalk between macrophages and other immune cells such as mast cells may affect their metabolic fates and enhance functional outcomes during immune activity

doi: 10.1111/and.13179 71 RhodesMACarrawayMSPiantadosiCAReynoldsCMCherryADWesterTEet al

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Supplementation of creatine + Guanidinoacetate was found to be superior for muscle performance than creatine alone, possibly reflecting better transport of guanidinoacetate than creatine