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Interestingly, hypoxia through HIF-1 significantly changes the function of MDSC in TME and shifts its differentiation direction to tumor-associated macrophages (TAMs) (286)

This kind of therapy would exert its beneficial action through antioxidant and immunoregulatory functions, optimizing mitochondrial function and even increasing the biogenesis of this vital organelle

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However, it is still unclear which P450 is responsible for these reactions since rifampicin and phenobarbital are non-specific P450 inducers