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47 Conclusion It is clear that B 12 is necessary for maintaining spinal cord function, and deficiency can result in SACD

Although folic acid is readily absorbed thanks to its single glutamate residue, it is not active as a coenzyme: the enzyme dihydrofolate reductase (DHFR) needs to convert it to tetrahydrofolate for further use [ R , R ]

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Yet it would take several decades before compelling evidence from epidemiological studies, such as Framingham (221) and MRFIT (222), demonstrated that elevated blood cholesterol levels were associated with increased risk of cardiovascular events (CVE)