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In obese male subjects, MK677 raised IGF1 by ~40%, promoted FFM gains, and transiently increased basal metabolic rate, although total and visceral fat did not significantly decrease [39,49]

Stimuliresponsive systems can release drugs in response to environmental cues that mirror active disease, such as the acidic microenvironment generated by inflammatory infiltrates or the presence of specific bacterial enzymes [180, 181, 182]

Florean et al., 2011

Technical References and Primary Literature M Heffernan 1, R J Summers, A Thorburn, E Ogru, R Gianello, W J Jiang, F M Ng
