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Official guidance from the Food and Drug Administration and Pfizer-BioNTech state that the two doses should be administered 21 days apart based on the results of clinical trials

[DOI] [PubMed] [Google Scholar] 40.Ferlay J, et al

further notes that a restricted maintenance dose of just four injections per year is what is normally allowed, which can leave people physically and mentally unable to contribute to either family or society, and lead to permanent neurological damage

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The latter assemble into long polymers that form a gel-like structure that can hold numerous bacteria