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Several metabolite biomarkers have been discovered by untargeted metabolic profiling of sperm samples from healthy individuals and infertile patients using different analytical techniques such as nuclear magnetic resonance (NMR) (124) and mass spectrometry (MS) (125)

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Muscles secrete myokines, such as irisin [72] and musclin [73], in response to exercise that mediate inter-organ communication and coordination [74]

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