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Inducible knockdown of STAT3 and ACSL4 in a paclitaxel resistant TNBC cell line decreased tumor growth and membrane lipids in vivo , suggesting that acetylated-STAT3 promotes FAO-mediated chemoresistance

[29] The effect on membrane fluidity is essential for animals living in cold water, as EPA and DHA also have an antifreeze function

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A critical factor in inducing ferroptosis is the imbalance of intracellular iron metabolism which could cause iron overload
