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Outcome measures include frailty status using Fried criteria and Frailty Index accumulation of deficit, selected frailty biomarkers (interleukin-6, tumor necrosis factor-alpha, and insulin-like growth factor-1), physical function, cognitive function, nutritional status and biochemical profile

[2]Collins, C. B., Riskowski, R. A., Ackerson, C.J. Radiofrequency remote control of thermolysin activity. Sci Rep 2021 Mar 16;11(1):6070. doi: 10.1038/s41598-021-85611-w