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The depletion of the ozone layer, over the past few decades, has increased the amount of solar UV radiation reaching the Earths surface [8], in particular UV-B levels, since UV-A is not absorbed by the ozone layer [9]

3.2.3 Cytosolic mtDNA and the cGAS-STING pathway mtDNA is particularly vulnerable to oxidative damage due to its lack of histone protection and proximity to ROS generation sites (Wang et al., 2025a
