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In PA patients the parietal cells that produce intrinsic factor is destroyed due to an autoimmune reaction that also leads to an atrophic gastritis

NNMT is an intracellular enzyme involved in nicotinamide metabolism and cellular methylation pathways

Results In the operated rats, at 24 and 72 hr of the reperfusion, the therapy counteracted both early and delayed neural hippocampal damage, achieving full functional recovery (Morris water maze test, inclined beamwalking test, lateral push test)

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