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C.ChangC

Bone regeneration around N-acetyl cysteine-loaded nanotube titanium dental implant in rat mandible

Vignery A, McCarthy TL
This leaves plenty of room for experimentationbut also a lot of room for error

Thus, although the combination of anti-complement therapies with other anti-cancer agents should be further investigated, the increasing number of studies that demonstrate the improved antitumor responses obtained combining complement inhibitionand in particular C5aR1 inhibitionwith chemotherapy and/or immunotherapy, together with our present results on paclitaxel-mediated C5aR1 activation, further sustain that a combined treatment with paclitaxel and C5aR1 inhibitors could be a promising therapeutic approach, not only to prevent CIPN and HSRs, but also to potentially obtain a synergistic effect on tumor progression