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407 Selecting potential subgroups for chemotherapy de-escalation still needs further validation

The metabolomic analysis revealed that the primary significantly enriched metabolic pathways in both the PD and normal control (NC) groups included glucose signaling, central carbon metabolism, the tricarboxylic acid (TCA) cycle, glycolysis, choline metabolism, and fatty acid metabolism

Environ Int 40:3943

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In addition, the membrane loss during splenic conditioning might further worsen the RBC metabolic setting, sustaining chronic hemolysis of HS
