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FIGURE 10 Oxidative stress, associated with high dose MTX, triggers a systemic inflammatory response where proinflammatory cytokines further contribute to tissue damage (Kalantar et al., 2019a

Amaravadi R, Kimmelman AC, White E

doi: 10.1080/21622965.2018.1428803
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Zhu and co-workers [51] developed a novel biocompatible melanin-based nanoprobe (PMNs-II-813) coupled with highly specific small-molecule inhibitors of prostate-specific membrane antigen, designed for precise multimodal diagnosis and treatment of prostate cancer
