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The hypoxia alleviation via O2 production, the redox balance disruption via glutathione consumption and the reactive oxygen species generation, together would down-regulate the expression of O6-methylguanine-DNA methyltransferase under TMZ medication, which is considered as the key to drug resistance
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Studied for IGF-1 signaling, cellular growth pathways, protein synthesis activity, and receptor interaction in controlled research environments.
