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Disclosure of interest: nothing to disclose Poster Session I - ACUTE ISCHEMIC STROKE MANAGEMENT 01.00 - ACUTE ISCHEMIC STROKE MANAGEMENT - 01.02 - ACUTE MANAGEMENT - Thrombolysis or thrombectomy P130 - ESOC25-1330 THE EFFICACY AND SAFETY OF EARLY BLOOD PRESSURE REDUCTION IN ACUTE STROKE WITH DIFFERENT REAL FUNCTION STATUS: A SYSTEMATIC REVIEW AND META-ANALYSIS Jie Yang 1 , Fengkai Mao 2 1 Department of neurology, Sichuan Provincial People's Hospital, School of Medicine,University of Electronic Science and Technology of China, Chengdu, China, Chengdu, China, 2 The First Affiliated Hospital of Chengdu Medical College, Chengdu, China, Chengdu, China Background and Aims: The management of blood pressure in acute stroke with different renal functional states remains controversial

The peptides ability to modulate SK channel activity has been linked to its therapeutic effects, as SK channels play a crucial role in neuronal excitability and synaptic plasticity